姓名：赵洪芝
职务职称：副教授（博士生导师、硕士生导师）
研究领域：环境与人体健康（新污染物的生物监测及健康效应等）
邮箱：hongzhizhao@nankai.edu.cn
教育背景
2009.9-2012.12 南开大学药学院化学生物学专业攻读博士学位
2003.9-2006.3 天津大学化工学院生物化工专业攻读硕士学位
1999.9-2003.7 天津大学化工学院制药工程专业攻读学士学位
科研教学经历
2019.9-至今 南开大学环境科学与工程学院，副教授
2024.12-2025.7 德国亥姆霍兹慕尼黑中心（Helmholtz Zentrum Munchen），国家公派访问学者
2014.7-2019.8 香港浸会大学（HKBU）环境与生物分析国家重点实验室，博士后
2013.3-2014.3 比利时鲁汶大学（K. U. Leuven）生物系，博士后
主讲课程：
《环境代谢组学》，研究生课程
《环境健康综合实验》，本科生课程
《多组学技术的环境健康应用》，本科生课程
学术与社会任职
Bulletin of Environmental Contamination and Toxicology 编委
南开大学生物医学伦理委员会委员
中国分析测试协会生命组学专业委员会委员
科研项目
1. 国家自然科学基金-面上项目，全多氟化合物暴露对人体糖脂代谢及其空间分布的影响机制研究（NSFC 42477466），2025年1月-2028年12月，主持；
2. 国家重点研发计划项目“典型化工园区及周边士壤-地下水中全氟和抗生素类新污染物风险诊断与管控技术研究”，课题三“PFAS和抗生素类新污染物人体健康危害与生态毒性表征”（2024YFC3712003），2024年12月-2027年11月，参与（子课题负责人）；
3. 国家重点研发计划项目“精细化工园区无卤阻燃剂暴露识别与风险分级技术（2024YFC3908600）”，课题四“精细化工业园区有机磷无卤阻燃剂健康风险分级边界模拟与验证”，2025年1月-2028年12月，参与
3. 国家自然科学基金-面上项目，基于代谢组学的邻苯二甲酸酯暴露及其与年龄交互作用导致妊娠糖尿病机制研究（NSFC 42177412），2022年1月-2025年12月，主持；
4. 国家重点研发计划项目“场地土壤污染物环境基准制定方法体系及关键技术”，课题二“本土化场地土壤环境暴露参数方法学与指标体系”（2019YFC1804602），2020年1月-2023年12月，参与（子课题负责人）；
5. 青年教师研究启动项目，“对羟基苯甲酸酯人体暴露与健康效应”，主持；
6.青年教师研究启动项目，“环境内分泌干扰物的人体暴露及其对健康的影响”，主持；
7.青年教师研究启动项目，“多环芳烃的人体暴露研究”，主持；
8. 国家自然科学基金-青年基金：基于质谱技术的双酚A与DNA加合物检测方法的研究及其应用（NSFC 21505111），2016年1月-2018年12月，主持；
个人学术网页：
Scopus：https://www.scopus.com/authid/detail.uri?authorId=55599190200
学术论著
发表SCI论文105篇，总引用3300余次，谷歌H指数34，其中以第一作者或通讯作者共发表SCI收录文章共34篇，部分代表作如下：
2. Wei Liu, Yawen Zheng, Yafei Gao, Wu Liu, Zhuoya Yu, Xinmiao Yu, Hongkai Zhu, Yiming Yao, Lin Zhu, Hongwen Sun, Hongzhi Zhao*, Association study of internal exposure levels of perfluoroalkyl substances and blood lipid levels in the elderly population and adverse outcome pathway analysis, Environmental Pollution, 2026, 392(1): 127644
3. Yafei Gao#, Chenran Cai#, Han Li, Lu Cheng, Hongkai Zhu, Hongwen Sun, Yang Peng*, Hongzhi Zhao*, The hidden mediator between polycyclic aromatic hydrocarbon exposure and cognitive function of elder adults: FT3/FT4 ratio, Environmental Chemistry and Ecotoxicology, 2026, 8: 418-429
4. Yafei Gao#, Biwen Wang#, Liting Hua, Juanhua Li, Junqi Liu, Yang Peng, Lu Cheng, Hongkai Zhu, Hongwen Sun, Han Li*, and Hongzhi Zhao*, Risk assessment and exposure patterns of hydroxypolycyclic aromatic hydrocarbons in elderly population: insights from urinary metabolite levels and dietary habits, Journal of Environmental Sciences, 2026, 163: 37-47
5. Yawen Zheng, Wei Liu, Mengqi Yan, Zhu Yang, Hongkai Zhu, Hongwen Sun, Hongzhi Zhao*, Quantitative identification and prioritization of combined effects of multiple endocrine disrupting compound exposure on oxidative stress, Journal of Hazardous Materials, 2025, 495: 138906
6. Yawen Zheng, Lei Zhang*, Qian Xiang, Jingguang Li, Yiming Yao, Yongning Wu, Hongwen Sun, Hongzhi Zhao*, Associations of pharmaceutical and personal care product chemical exposure with thyroid nodules and thyroid homeostasis, Journal of Environmental Sciences, 2025, 157: 21-34
7. Liting Hua, Yafei Gao, Sai Guo, Hongkai Zhu, Yiming Yao，Beibei Wang，Jing Fang, Hongwen Sun, Fu-Liu Xu, Hongzhi Zhao*, Urinary metabolites of polycyclic aromatic hydrocarbons of rural population in Northwestern China: Oxidative stress and health risk assessment, Environmental Science & Technology, 2024, 58, 18: 7758–7769
8. Yuanyuan Zheng, Lu Wang, Jianing Wu, Li Xiang, Yafei Gao, Hao Chen, Hongwen Sun, Yuanjiang Pan*, Hongzhi Zhao*, Integrated non-targeted metabolomics and lipidomics reveal mechanisms of fluorotelomer sulfonates-induced toxicity in human hepatocytes, Environment International, 2024, 193: 109092
9. Yawen Zheng, Lei Zhang, Qian Xiang, Jingguang Li, Yiming Yao, Hongwen Sun, Hongzhi Zhao*, Human exposure characteristics of pharmaceutical and personal care product chemicals and associations with dietary habits, Science of The Total Environment, 2024, 939: 173540
10. Yawen Zheng, Liting Hua, Zining Zhang, Lin Zhu, Hongkai Zhu, Hongwen Sun, Hongzhi Zhao*, Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study, Environment & Health, 2024,8: 586-595
11. Yawen Zheng, Yarui Liu, Zining Zhang, Liting Hua, Jing Fang, Lei Wang, Hongzhi Zhao*, A fast method for the determination of personal care product chemicals in human urine using dispersive liquid–liquid extraction and ultra high-performance liquid chromatography–tandem mass spectrometry, Rapid communications in mass spectrometry, 2024, 38(6): e9684
12. Yuanyuan Zheng, Mian Bao, Yiming Yao, Maosen Zhao, Hao Chen, Hongwen Sun, Cuirong Sun, Hongzhi Zhao*, Yuanjing Pan*, Discovery of 35 novel classes of per- and polyfluoroalkyl substances in representative commercial fluorinated products in China, Journal of Hazardous Materials, 2023, 457: 131780
13. Zining Zhang, Sai Guo, Liting Hua, Beibei Wang, Qiusheng Chen, Lu Liu, Li Xiang, Hongwen Sun, Hongzhi Zhao*, Urinary levels of 14 metal elements in general population: A region-based exploratory study in China, Toxics, 2023, 11(6): 488
14. Sai Guo, Liting Hua, Wu Liu, Hongxiu Liu, Qiusheng Chen, Yongcheng Li, Xiaoxiao Li, Leicheng Zhao, Ruoqi Li, Zining Zhang, Chong Zhang, Lin Zhu, Hongwen Sun, Hongzhi Zhao*, Multiple metal exposure and metabolic syndrome in elderly individuals: A case-control study in an active mining district, Northwest China, Chemosphere, 2023, 326:138494
15. Liting Hua#, Wu Liu#, Yarui Liu, Ming Yang, Beibei Wang, Hongkai Zhu, Lin Zhu, Yiming Yao, Yuqin Zhang, Hongzhi Zhao*, Occurrence and profile characteristics of environmental phenols in human urine from a rural area in Northwestern China, Environmental Pollution, 2022, 315:120405
16. Liting Hua, Sai Guo, Jiaping Xu, Xiaomeng Yang, Hongkai Zhu, Yiming Yao, Lin Zhu, Yongcheng Li, Jingran Zhang, Hongwen Sun, Hongzhi Zhao*,Phthalates in dormitory dust and human urine: A study of exposure characteristics and risk assessments of university students,Science of the Total Environment, 2022, 845: 157251
17. Hongzhi Zhao, Yuanyuan Zheng, Lin Zhu, Li Xiang, Shunqing Xu*, Zongwei Cai*, Trimester-specific urinary metabolome alterations associated with gestational diabetes mellitus: A study in different pregnancy stages, Chinese Chemical Letters, 2022, 33(6): 3139-3143
18. Liting Hua, Sai Guo, Yu Wang, Hongwen Sun*, Hongzhi Zhao*, Simultaneous determination of multiple isomeric hydroxylated polycyclic aromatic hydrocarbons in urine by using ultra-high performance liquid chromatography tandem mass spectrometry, Journal of Chromatography B, 2021,1184: 122983
19. Xiaoxiao Wang, Guodong Cao, Zhiyi Yang, Hongzhi Zhao*, Zongwei Cai*, DNA and RNA adducts formation from 3,4-quinone metabolites of bisphenol F, Environmental Science & Technology Letters, 2021, 8(11): 1009-1014
20. Yuanyuan Zheng#, Hongzhi Zhao#, Man Tong, Lin Zhu, Stephanie Ma*, Zongwei Cai*, Characterization and determination of 13C-labeled non-essential amino acids in 13C5-glutamine isotope tracer experiment with a mass spectrometry strategy combining parallel reaction monitoring and multiple reaction monitoring, Analytical Chemistry, 2021, 93(40): 13564-13571 (co-first author)
21. Hongzhi Zhao#, Yuanyuan Zheng#, Lin Zhu, Li Xiang, Yanqiu Zhou, Jiufeng Li, Jing Fang, Shunqing Xu, Wei Xia*, Zongwei Cai*, Paraben exposure related to purine metabolism and other pathways revealed by mass spectrometry-based metabolomics,Environmental Science & Technology, 2020, 54(6): 3447-3454
22. Hongzhi Zhao#, Han Li#, Yuanyuan Zheng, Lin Zhu, Jing Fang, Li Xiang, Shunqing Xu, Yanqiu Zhou, Hemi Luan, Wei Xia*, Zongwei Cai*, Association of altered serum acylcarnitine levels in early pregnancy and risk of gestational diabetes mellitus, SCIENCE CHINA Chemistry, 2020, 63(1): 126-134
23. Jie Hu#, Hongzhi Zhao#,Joseph M, Braun, Tongzhang Zheng, Bin Zhang, Wei Xia, Wenxin Zhang, Jiufeng Li, Yanqiu Zhou, Han Li, Jun Li, Aifen Zhou, Yiming Zhang, Stephen L, Buka, Simin Liu, Yang Peng, Chuansha Wu, Minmin Jiang, Wenqian Huo, Yingshuang Zhu, Kunchong Shi, Yuanyuan Li, Zongwei Cai*, Shunqing Xu*, Associations of trimester-specific exposure to bisphenols with size at birth: A Chinese prenatal cohort study, Environmental Health Perspectives, 2019, 127(10): 107001 (co-first author)
24. Yangqian Jiang#, Hongzhi Zhao#,Wei Xia, Yuanyuan Li, Hongxiu Liu, Ke Hao, Jia Chen, Xiaojie Sun, Wenyu Liu, Jiufeng Li, Yang Peng, Chen Hu, Chunhui Li, Bin Zhang, Shi Lu, Zongwei Cai*, Shunqing Xu*, Prenatal exposure to benzophenones, parabens and triclosan and neurocognitive development at 2 years, Environment International, 2019, 126: 413-421 (co-first author)
25. Hongzhi Zhao#, Han Li#, Arthur Chi Kong Chung, Li Xiang, Xiaona Li, Yuanyuan Zheng, Hemi Luan, Lin Zhu, Wenyu Liu, Yang Peng, Yaxing Zhao, Shunqing Xu, Yuanyuan Li*, Zongwei Cai*, Large-scale longitudinal metabolomics study reveals different trimester-specific alterations of metabolites in relation to gestational diabetes mellitus, Journal of Proteome Research, 2019, 18 (1): 292-300
26. Yuanyuan Zheng#, Hongzhi Zhao#, Lin Zhu, Zongwei Cai*, Comprehensive identification of steroid hormones in human urine based on liquid chromatography-high resolution mass spectrometry, Analytica Chimica Acta, 2019, 1089:100-107 (co-first author)
27. Hongzhi Zhao, Jiufeng Li, Yanqiu Zhou, Lin Zhu, Yuanyuan Zheng, Wei Xia, Yuanyuan Li, Li Xiang, Wei Chen, Shunqing Xu*, Zongwei Cai*, Investigation on metabolism of di(2-ethylhexyl) phthalate in different trimesters of pregnant women, Environmental Science & Technology, 2018, 52(21): 12851-12858
28. Hongzhi Zhao, Juntong Wei, Li Xiang, Zongwei Cai*, Mass spectrometry investigation of DNA adduct formation from bisphenol A quinone metabolite and MCF-7 cell DNA, Talanta, 2018,182(5): 583-589
29. Hongzhi Zhao, Jiufeng Li, Xinli Ma, Wenqian Huo, Shunqing Xu*, Zongwei Cai*, Simultaneous determination of bisphenols, benzophenones and parabens in human urine by using UHPLC-TQMS, Chinese Chemical Letters, 2018, 29:102-106
30. Hongzhi Zhao#, Wenqian Huo#, Jiufeng Li, Xinli Ma, Wei Xia, Zhengji Pang, Mingyi Xie, Shunqing Xu*, Zongwei Cai*,Exposure to benzophenones, parabens and triclosan among pregnant women in different trimesters, Science of the Total Environment, 2017, 607-608:578-585
荣誉与奖励
1. 天津市“青年高层次人才项目”，2020年
2. 南开大学优秀硕士论文指导教师（2025年），“药品及个人护理品的人群暴露特征及其与不良健康结局的关联研究”
3. 协助指导硕士生获得南开大学优秀硕士学位论文（2022年），“典型环境内分泌干扰物的人体暴露评估研究”
4. 指导本科生获得环境科学与工程学院优秀毕业论文（2022年），“重金属暴露与血压的关联性研究”
