陈则友

发布者:envadmin发布时间:2019-06-12浏览次数:8774


姓名:陈则友
职称:副教授

研究领域:环境微生物学、微生物生态学、环境化学

研究兴趣:1. 抗生素的环境行为过程(生物/非生物转化等)和生态健康危害(生物可利用性、诱导细菌耐药、对肠道菌群的影响等);

          2. 环境抗生素抗性组(抗性基因和抗性细菌)的来源分布、传播扩散和健康风险。

邮箱: zeyou@nankai.edu.cn

教育背景

2013.10—2016.6,美国密西根州立大学,联合培养博士
2010.9—2016.6,南京农业大学,硕博连读

科研教学经历

2019.02至今,南开大学,副教授
2017.12-2018.12,南京大学,助理研究员
2016.6-2017.11,美国密西根州立大学,博士后

科研项目

1. 国家重点研发计划“场地土壤污染成因与治理技术”2020年度重点专项(2020YFC1806900),场地抗生素及抗性基因环境行为与健康风险,100万,2020.11-2024.10(子课题负责人)。

2. 国家自然科学基金面上项目(41977367),耐药性人类条件致病菌及其携带的耐药基因在土壤-植物系统中的传输规律、扩散机制及健康风险研究,61万,2020.1-2023.12(主持)。

3. 国家自然科学基金青年项目(41807483),利用全细胞微生物传感器研究四环素的典型环境行为对细菌抗性基因表达的影响及机理,25万,2019.1-2021.12(主持)。

4. 江苏省自然科学基金青年项目(BK20180347),抗生素抗性基因在动物粪便-好氧堆肥-农田施用全过程中的迁移和归趋研究,20万,2018.7-2021.6(主持)。

5. 南京大学中央高校基本科研业务费专项资金资助(021114380099)。利用全细胞微生物传感器研究四环素的典型环境行为对细菌抗性基因表达的影响及机理,10万,2018.1-2018.12(主持)。

学术论著

学术论著 (#co-first author,* corresponding author

 

1. Han Xu, Zeyou Chen *, Ruiyang Huang, Yuxiao Cui, Qiang Li, Yanhui Zhao, Xiaolong Wang, Daqing Mao, Yi Luo *.Antibiotic Resistance Genes-carrying Plasmid Spreads into the Plant Endophytic Bacteria by Soil Bacteria as Carriers.Environmental Science & Technology. 2021, 10.1021/acs. est.1c01615.

2. Zeyou Chen, Siyuan Zhu, Lin Zhao, Xiaolong Wang, Minmin Liang, Daqing Mao, Yi Luo, and Hongqiang Ren. Occurrence of high-risk mcr-1 gene and blaNDM-1 positive superbug in the reverse osmosis filter cartridges of the household water purifiers.Journal of Hazardous Materials Letters. 2021:2:100011.  

3. Xiaolong Wang (#), Zeyou Chen(#), Quanhua Mu(#), Xinyan Wu, Jingjing Zhang, Daqing Mao, Yi Luo, Pedro J. J. Alvarez, Ionic liquid Enriches the Antibiotic Resistome, Especially Efflux Pump Genes, Before Significantly Affecting Microbial Community Structure.Environmental Science & Technology,2020, 54, 7, 4305-4315

4. Zeyou Chen, Wei Zhang, Wang Gang, Yingjie Zhang, Yanzheng Gao, Stephen A. Boyd, Brian J. Teppen, James M. Tiedje, Dongqiang Zhu, and Hui Li. Bioavailability of Soil-sorbed Tetracycline to Escherichia coli under Unsaturated Conditions. Environmental Science and Technology. 2017:51:6165-6173.

5.  Zeyou Chen, Yingjie Zhang, Yanzheng Gao, Stephen A. Boyd, Dongqiang Zhu, and Hui Li. Influence of Dissolved Organic Matter on Tetracycline Bioavailability to an Antibiotic-Resistant Bacterium. Environmental Science and Technology. 2015:49: 10903−10910.

6. Jie Hou(#), Zeyou Chen (#), Ju Gao, Yonglei Xie, Linyun Li, Songyan Qin, Qing Wang, Daqing Mao, Yi Luo, Simultaneous removal of antibiotics and antibiotic resistance genes from pharmaceutical wastewater using the combinations of up-flow anaerobic sludge bed, anoxic-oxic tank, and advanced oxidation technologies. Water Research, 2019:159:511-520.

7. Zeyou Chen, Hui Li, Yanzheng Gao, and Anping Peng.  Removal of Phenanthrene and Acenaphthene from Aqueous Solution by Enzyme-catalyzed Phenol Coupling Reactions. Chemical Engineering Journal. 2015:265:27–33.

8. Zeyou Chen, Wei Zhang, Luxi Yang, Robert D. Stedtfeld, Anping Peng, Cheng Gu, Stephen A. Boyd, and Hui Li. Antibiotic Resistance Genes and Bacterial Communities in Cornfield and Pasture Soils Receiving Swine and Dairy Manures. Environmental Pollution, 2019:248:947-957.

9. Yujing Duan(#), Zeyou Chen(#), Lu Tan, Xiaolong Wang, Yingang Xue, Shaopeng Wang, Qing Wang, Ranjit Das, Huai Lin, Jie Hou, Linyun Li, Daqing Mao, Yi Luo,Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals.Science of The Total Environment, 2020:705:135674.

10. Yanhui Zhao(#), Zeyou Chen (#). Jie Hou, Daqing Mao, Huai Lin, Yingang Xue, Yi Luo. Monitoring antibiotic resistomes and bacterial microbiomes in the aerosols from fine, hazy, and dusty weather in Tianjin, China using a developed high-volume tandem liquid impinging sampler. Science of The Total Environment 2020, 731, 139242.

11. Han Xu(#), Zeyou Chen(#), Xinyan Wu, Lin Zhao, Nan Wang, Daqing Mao, Hongqiang Ren, Yi Luo. Antibiotic contamination amplifies the impact of foreign antibiotic-resistant bacteria on soil bacterial community.Science of The Total Environment, 2020:23;143693.

12. Zeyou Chen, Hui Li, Anping Peng, and Yanzheng Gao. Oxidation of Polycyclic Aromatic Hydrocarbons by Horseradish Peroxidase in Water Containing OrganicCosolvent. Environmental Science and Pollution Research. 2014:21:10696-10705.

13. Xin Jin, Dingding Wu, Zeyou Chen, Chao Wang, Cun Liu, Cheng Gu.Surface Catalyzed Hydrolysis of Chloramphenicol Antibiotic by Montmorillonite under Limited Surface Moisture Conditions. Science of The Total Environment, 2021. In press.

14. Yanhui Zhao, Qing Wang, Zeyou Chen, Daqing Mao, Yi Luo. Significant higher airborne antibiotic resistance genes and the associated inhalation risk in the indoor than the outdoor. Environmental Pollution 2021: 268: 115620.

15. Lin, Huai, Wang Qing, Meng Yuan, Lei Liu, Zeyou Chen, Ranjit Das, Yi Luo, and Daqing Mao. Colonization of mice with amoxicillin-associated Klebsiella variicola drives inflammation via Th1 induction and Treg inhibition. Frontiers in Microbiology 11 (2020): 1256.

16. Huai Lin(#), Qing Wang(#), Meng Yuan, Lei Liu, Zeyou Chen, Yanhui Zhao, Ranjit Das, Yujing Duan, Ximing Xu, Yingang Xue, Yi Luo, Daqing Mao.The prolonged disruption of a single-course amoxicillin on mice gut microbiota and resistome, and recovery by inulin, Bifidobacterium longum and fecal microbiota transplantation. Environmental Pollution. 2020: 265: 114651.

17. Yi Wang, Anping Peng, Zeyou Chen, Xin Jin, Cheng Gu. Transformation of gaseous 2-bromophenol on clay mineral dust and the potential health effect. Environmental Pollution. 2019. 250:686-694.

18. Anping Peng, Juan Gao, Zeyou Chen, Yi Wang, Hui Li, Lena Q. Ma, and Cheng Gu. Interactions of Gaseous 2-Chlorophenol with Fe3+-Saturated Montmorillonite and their Toxicity to Human Lung Cells. Environmental science & technology. 2018, 52 (9):5208–5217.

19. Anping Peng, Mengyu Huang, Zeyou Chen, and Cheng Gu. Oxidative Coupling of Acetaminophen Mediated by Fe3+-saturated Montmorillonite. Science of the Total Environment, 2017: 595: 673-680.

20. Anping Peng, Juan Liu, Wanting Ling, Zeyou Chen, and Yanzheng Gao. Diversity and Distribution of 16S rRNA and Phenol Monooxygenase Genes in the Rhizosphere and Endophytic Bacteria Isolated from PAH-contaminated Sites. Scientific Reports. 2015: 5: 12173.

21. Anping Peng, Juan Liu, Yanzheng Gao, Zeyou Chen. Distribution of Endophytic Bacteria in Alopecurus aequalis Sobol and Oxalis corniculata L. from Soils Contaminated by Polycyclic Aromatic Hydrocarbons, PLoS ONE, 2013: 8(12): e83054.