陈则友

发布者:envadmin发布时间:2019-06-12浏览次数:18660


姓名:陈则友
职称:副教授

研究领域:环境微生物学、微生物生态学、环境化学

研究兴趣:

1. 抗生素的环境行为过程和生态健康危害;

2. 环境中抗生素抗性基因和抗性细菌的来源分布、传播扩散和健康风险。

邮箱: zeyou@nankai.edu.cn

教育背景

2013.10—2016.6,美国密西根州立大学,联合培养博士
2010.9—2016.6,南京农业大学,硕博连读

科研教学经历

2019.02至今,南开大学,环境科学与工程学院,副教授

2017.12-2018.12,南京大学,环境学院,助理研究员

2016.6-2017.11,美国密西根州立大学,土壤、植物和微生物系,博士后

2020年至今,讲授本科生课程《简明分子生物学》。

科研项目

1. 国家自然科学基金面上项目(42277386, 消毒剂协同选择公共设施表面细菌产生抗生素抗性的机制和风险,53万,2023,1-2026.12(主持)。

2. 国家重点研发计划青年科学家项目(2022YFC3700216),土壤及地下水中高风险病原体污染及防控,60万,2023.1-2025.12(课题负责人)。

3. 国家重点研发计划 “场地土壤污染成因与治理技术”2020年度重点专项(2020YFC1806900),场地抗生素及抗性基因环境行为与健康风险,100万,2020.11-2024.10(子课题负责人)。

4. 国家自然科学基金面上项目(41977367),耐药性人类条件致病菌及其携带的耐药基因在土壤-植物系统中的传输规律、扩散机制及健康风险研究,61万,2020.1-2023.12(主持)。

5. 国家自然科学基金青年项目(41807483),利用全细胞微生物传感器研究四环素的典型环境行为对细菌抗性基因表达的影响及机理,25万,2019.1-2021.12(主持)。

6. 江苏省自然科学基金青年项目(BK20180347),抗生素抗性基因在动物粪便-好氧堆肥-农田施用全过程中的迁移和归趋研究,20万,2018.7-2021.6(主持)。

7. 南京大学中央高校基本科研业务费专项资金资助(021114380099)。利用全细胞微生物传感器研究四环素的典型环境行为对细菌抗性基因表达的影响及机理,10万,2018.1-2018.12(主持)。


学术与社会任职

1.   1. Journal of Hazardous Materials Advances 青年编委

2.   2.  Bulletin of Environmental Contamination and Toxicology (BECT) 青年编委

3.   3.  Frontiers in Microbiology 专刊客座编辑

4.   4. “Environmental Microbiology, Environmental Science & Technology, Water Research”等杂志审稿人


学术论著

代表性著作#co-first author,* corresponding author


1.        Lichun Yin, Xiaolong Wang, Han Xu, Bo Yin, Xingshuo Wang, Yulin Zhang, Xinyao Li, Yi Luo, Zeyou Chen*, Unrecognized Risk of Perfluorooctane Sulfonate in Promoting Conjugative Transfers of Bacterial Antibiotic Resistance Genes. Applied and Environmental Microbiology. 2023. In press.

2.        Zeyou Chen, Wei Zhang, Anping Peng, Yike Shen, Xin Jin, Robert D. Stedtfeld, Stephen A. Boyd, Brian J. Teppen, James M. Tiedje, Cheng Gu, Dongqiang Zhu, Yi Luo, Hui Li*.Bacterial Community Assembly and Antibiotic Resistance Genes in Soils Exposed to Antibiotics at Environmentally Relevant Concentrations. Environmental Microbiology. 2023. DOI: 10.1111/1462-2920.16371.

3.        Lichun Yin, Xingshuo Wang, Yangyang Li, Ziyin Liu, Qinyuan Mei, Zeyou Chen*.Uptake of the Plant Agriculture-used Antibiotics Oxytetracycline and Streptomycin by Cherry Radish, Effect on Plant Microbiome and the Potential Health Risk. Journal of Agricultural and Food Chemistry, 2023.DOI: 10.1021/acs.jafc.3c01052.

4.        Anping Peng, Hu Gao, Huimin Wang,Yi Wang, Zeyou Chen*, Influence of organic cosolvents on hexabromobenzene degradation in solution by montmorillonite-templated subnanoscale zero-valent iron. Environmental Research. 2023, 229, 115986.

5.        Anping Peng, Chao Wang, Zhanhua Zhang, Xin Jin, Cheng Gu, and Zeyou Chen, * Tetracycline photolysis revisited: overlooked day-night succession of the parent and metabolites in natural surface waters and associated ecotoxicity. Water Research. 2022, 225:119197.

6.        Han Xu, Zeyou Chen *, Ruiyang Huang, Yuxiao Cui, Qiang Li, Yanhui Zhao, Xiaolong Wang, Daqing Mao, Yi Luo *.Antibiotic Resistance Genes-carrying Plasmid Spreads into the Plant Endophytic Bacteria by Soil Bacteria as Carriers. Environmental Science & Technology. 2021, 55(15)10462-10470.

7.        Xiaolong Wang(#), Zeyou Chen(#), Quanhua Mu(#), Xinyan Wu, Jingjing Zhang, Daqing Mao, Yi Luo, Pedro J. J. Alvarez, Ionic liquid Enriches the Antibiotic Resistome, Especially Efflux Pump Genes, Before Significantly Affecting Microbial Community Structure.Environmental Science & Technology,2020, 54, 7, 4305-4315

8.        Zeyou Chen, Wei Zhang, Wang Gang, Yingjie Zhang, Yanzheng Gao, Stephen A. Boyd, Brian J. Teppen, James M. Tiedje, Dongqiang Zhu, and Hui Li. Bioavailability of Soil-sorbed Tetracycline to Escherichia coli under Unsaturated Conditions. Environmental Science & Technology. 2017:51:6165-6173.

9.        Zeyou Chen, Yingjie Zhang, Yanzheng Gao, Stephen A. Boyd, Dongqiang Zhu, and Hui Li. Influence of Dissolved Organic Matter on Tetracycline Bioavailability to an Antibiotic-Resistant Bacterium. Environmental Science & Technology. 2015:49: 10903−10910.

10.    Jie Hou(#), Zeyou Chen (#), Ju Gao, Yonglei Xie, Linyun Li, Songyan Qin, Qing Wang, Daqing Mao, Yi Luo, Simultaneous removal of antibiotics and antibiotic resistance genes from pharmaceutical wastewater using the combinations of up-flow anaerobic sludge bed, anoxic-oxic tank, and advanced oxidation technologies. Water Research, 2019:159:511-520.

11.    Zeyou Chen, Hui Li, Yanzheng Gao, and Anping Peng.  Removal of Phenanthrene and Acenaphthene from Aqueous Solution by Enzyme-catalyzed Phenol Coupling Reactions. Chemical Engineering Journal. 2015:265:27–33.

12.    Zeyou Chen(#), Yujing Duan (#), Lichun Yin, Ying Chen, Yingang Xue, Xiaolong Wang, Daqing Mao, Yi Luo. Unraveling the influence of human fecal pollution on antibiotic resistance gene levels in different receiving water bodies using crAssphage indicator gene.Journal of Hazardous Materials. 2022,130005.

13.    Zeyou Chen, Wei Zhang, Luxi Yang, Robert D. Stedtfeld, Anping Peng, Cheng Gu, Stephen A. Boyd, and Hui Li. Antibiotic Resistance Genes and Bacterial Communities in Cornfield and Pasture Soils Receiving Swine and Dairy Manures. Environmental Pollution, 2019:248:947-957.

14.    Anping Peng, Yi Wang, Lichun Yin, Zeyou Chen*, Cheng Gu. Halide salts induced the photodegradation of a fat-burning compound 2, 4-dinitrophenol by iron-montmorillonite. Chemosphere2022291: 132694.

15.    Yujing Duan(#), Zeyou Chen(#), Lu Tan, Xiaolong Wang, Yingang Xue, Shaopeng Wang, Qing Wang, Ranjit Das, Huai Lin, Jie Hou, Linyun Li, Daqing Mao, Yi Luo,Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals.Science of The Total Environment, 2020:705:135674.

16.    Zeyou Chen, Lichun Yin, Wei Zhang, Anping Peng, J Brett Sallach, Yi Luo, Hui Li. NaCl salinity enhances tetracycline bioavailability to Escherichia coli on agar surfaces. Chemosphere, 2022, 134921.

17.    Yanhui Zhao(#), Zeyou Chen (#). Jie Hou, Daqing Mao, Huai Lin, Yingang Xue, Yi Luo. Monitoring antibiotic resistomes and bacterial microbiomes in the aerosols from fine, hazy, and dusty weather in Tianjin, China using a developed high-volume tandem liquid impinging sampler. Science of The Total Environment 2020, 731, 139242.

18.    Zeyou Chen, Hui Li, Anping Peng, and Yanzheng Gao. Oxidation of Polycyclic Aromatic Hydrocarbons by Horseradish Peroxidase in Water Containing OrganicCosolvent. Environmental Science and Pollution Research. 2014:21:10696-10705.

19.    Han Xu(#), Zeyou Chen(#), Xinyan Wu, Lin Zhao, Nan Wang, Daqing Mao, Hongqiang Ren, Yi Luo. Antibiotic contamination amplifies the impact of foreign antibiotic-resistant bacteria on soil bacterial community.Science of The Total Environment, 2020:23;143693.

20.    Zeyou Chen, Siyuan Zhu, Lin Zhao, Xiaolong Wang, Minmin Liang, Daqing Mao, Yi Luo, and Hongqiang Ren. Occurrence of high-risk mcr-1 gene and blaNDM-1 positive superbug in the reverse osmosis filter cartridges of the household water purifiers.Journal of Hazardous Materials Letters. 2021:2:100011.